bay 069

BAY-069 是一种抑制剂。BAY-069对支链氨基酸转氨酶 1 (BCAT1）具有抑制作用（IC50：31 nM ，对支链氨基酸转氨酶 2 （BCAT2) 具有抑制作用（IC50 ：153 nM）。BAY-069 是一种新型(三氟甲基)嘧啶二酮类化学探针， 可用于抗癌研究。

BAY-771 is a negative control of BAY-069, BAY-069 is a BCAT1 2 Inhibitor and Chemical Probe. BAY-069 displays high cellular activity and very good selectivity. BAY-069 displays high cellular activity. Its overall in vivo pharmacokinetic profile and its selectivity in various in vitro panels suggest that BAY-069 is suitable for in vivo experiments.

BAY-252为一种高效的BCAT1及BCAT2 (支链氨基酸转氨酶 1 和 2) 抑制剂，其IC50均值为2 μM。作为化学探针，BAY-252亦适用于癌症研究领域。