anticonvulsant agent 1

Anticonvulsant agent 1 is an anticonvulsant compound.

5-[(1S,2S)-2-[(Cyclopropylmethyl)amino]cyclopropyl]-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide hydrochloride 是一种环丙酶化合物，可作为赖氨酸特异性脱甲基酶-1抑制剂，可用于精神分裂症、发育障碍和神经退行性疾病。

GABAA receptor agent 1 是GABAA 受体的高亲和力配体，有抗惊厥活性。

Methsuximide 是一种抗惊厥药，对于癫痫小发作、精神运动和局灶性运动发作有效。

3-Methyl-GABA 是一种有效的GABA 氨基转移酶激活剂。3-Methyl-GABA 能与 GABAA 受体 (GABAaR) 结合。3-Methyl-GABA 能够激活 L-谷氨酸脱羧酶 (GAD)，表现出抗惊厥作用。

Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium current.3 Zonisamide inhibits H. pylori recombinant carbonic anhydrase (CA) and the human CA isoforms I, II, and V with Ki values of 218, 56, 35, and 21 nM, respectively.4,5 In mice, it has anticonvulsant activity against maximal electroshock seizure (MES) and pentylenetetrazole-induced maximal, but not minimal, seizures (ED50s = 19.6, 9.3, and >500 mg kg, respectively). Zonisamide (40 mg kg, p.o.) prevents MPTP-induced decreases in the levels of dopamine , but not homovanillic acid or dihydroxyphenyl acetic acid , and increases MPTP-induced decreases in the dopamine turnover rate in mouse striatum in a model of Parkinson's disease.6 Formulations containing zonisamide have been used in the treatment of partial seizures in adults with epilepsy. |1. Masuda, Y., Ishizaki, M., and Shimizu, M. Zonisamide: Pharmacology and clinical efficacy in epilepsy. CNS Drug Rev. 4(4), 341-360 (1998).|2. Rock, D.M., Macdonald, R.L., and Taylor, C.P. Blockade of sustained repetitive action potentials in cultured spinal cord neurons by zonisamide (AD 810, CI 912), a novel anticonvulsant. Epilepsy Res. 3(2), 138-143 (1989).|3. Suzuki, S., Kawakami, K., Nishimura, S., et al. Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex. Epilepsy Res. 12(1), 21-27 (1992).|4. Nishimori, I., Vullo, D., Minakuchi, T., et al. Carbonic anhydrase inhibitors: Cloning and sulfonamide inhibition studies of a carboxyterminal truncated α-carbonic anhydrase from Helicobacter pylori. Bioorg. Med. Chem. Lett. 16(8), 2182-2188 (2006).|5. De Simone, G., Di Fiore, A., Menchise, V., et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: Solution and X-ray crystallographic studies. Bioorg. Med. Chem. Lett. 15(9), 2315-2320 (2005).|6. Yabe, H., Choudhury, M.E., Kubo, M., et al. Zonisamide increases dopamine turnover in the striatum of mice and common marmosets treated with MPTP. J. Pharmacol. Sci. 110(1), 64-68 (2009).

Lamotrigine hydrate 是口服有效的抗惊厥剂或抗癫痫剂 ，通过选择性地阻断电压门控Na+通道，稳定突触前神经元膜并抑制谷氨酸释放。Lamotrigine hydrate 可用于研究癫痫、局灶性癫痫等神经性疾病。

GABAA receptor agent 8 (compoud 5e) 在癫痫研究方面具有潜力。GABAA receptor agent 8 是GABAA 受体的正向变构调节剂，在体内外均具有抗惊厥活性和低神经毒性。

GABAA receptor agent 7 (compoud 5c) 在体内外均具有抗惊厥活性和低神经毒性，可用于癫痫研究。 GABAA receptor agent 7 是GABAA 受体的有效正调节剂。

3 (Anticonvulsant agent) 是一种具有抗惊厥活性的2-氨基衍生物。

Ethotoin (Peganone) 是一种用于癫痫研究的，具有口服活性的抗惊厥剂。Ethotoin 是一种海因类化合物，与苯妥英相似。

VH-N412是一种载体化神经肽(NT)，能有效穿透血脑屏障。该化合物能同时与低密度脂蛋白受体(LDLR)及神经肽受体1(NTSR-1)结合，具有诱导药理性低体温(PIH)的能力。VH-N412不仅展现出抗惊厥效果，还具备神经保护功能，适用于探究癫痫等神经系统疾病。