anti tnbc agent 1

anti-TNBC agent-1 is a highly effective compound specifically designed to target and combat triple-negative breast cancer (TNBC). It demonstrates remarkable potency against various breast cancer cell types, with IC50 values spanning from 0.20 μM to 0.27 μM. The mechanism of action of anti-TNBC agent-1 involves inducing apoptosis in SUM-159 cells through the mitochondria pathway, as well as causing G1 phase arrest in these cells.

Anti-TNBC agent-3 (compound 3g) 作为凋亡诱导剂，展现了抗增殖活性针对癌细胞。在三阴性乳腺癌(TNBC)异种移植模型上，该化合物有效地抑制了肿瘤生长及其转移。

Anti-TNBC agent-2（3j）是一款针对三阴性乳腺癌（TNBC）的嘌呤衍生化合物。它能够引导MDA-MB-231细胞走向凋亡（apoptosis），阻碍其迁移和血管生成能力，并在TNBC异种移植模型中，抑制肿瘤生长与转移，同时下调Ki67和CD31蛋白的表达水平。Anti-TNBC agent-2主要用于三阴性乳腺癌的科研领域。