amplitudes

NS5806 是钾电流的激活剂，可增加 KV4.3/KChIP2峰值电流幅度，EC50值为 5.3 μM。它会在包含 KChIP2 的通道复合体中降低 KV4.2 和 KV4.3 电流衰减。

ICA-105574 (ICA) 是 hERG 通道激活剂。它通过消除 hERG 通道的失活从而增强 hERG 通道活性。它可以把电流幅度急剧增加到原来的 10 倍以上，其EC50值为 0.5 +/- 0.1 μM，Hill 斜率 (n(H)) 为 3.3 +/- 0.2。

EYE-003是一种可口服的RPE65抑制剂，其IC50值为102 nM。EYE-003通过减少11-cis-Retinal (11cRAL) 的合成并增加全反式视黄酯 (atREs)，调节小鼠的视觉循环。EYE-003能够抑制暗视视觉诱发的视网膜电图 (ERG) b-波振幅，并在Abca4⁻/⁻Rdh8⁻/⁻小鼠中以剂量依赖的方式减少视网膜自发荧光斑点，保护外核层 (ONL) 的厚度，从而对视网膜变性起到保护作用。EYE-003适用于研究与视觉循环相关的视网膜病变，例如斯塔加特病1型 (STGD1)。

EYE-002 是一种 RPE65 抑制剂，其 IC50 值为 69 nM。该化合物促进小鼠暗视视网膜电图 (ERG) a-/b-波振幅的恢复，并通过减少 11-cisretinal (11cRAL) 的合成和增加全反式视黄酯 (atREs)，调节小鼠的视觉循环。EYE-002 对于小鼠的光性视网膜损伤具有保护作用，适用于研究与视觉循环相关的视网膜病变，如斯塔加特病 1 型 (STGD1)。

Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997). Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) larval neurons (IC50s = 20.2 and 39.6 nM, respectively) but has no effect on chicken α3β4-, α4β2-, and α7-containing nAChRs.2 Dietary administration of aspergillimide A (10 μg/g of diet) induces paralysis in silkworm fourth instar larvae.1 Aspergillimide A (10 and 20 mg/kg) reduces T. colubriformis fecal egg count in gerbils.3 References1. Hayashi, H., Nishimoto, Y., Akiyama, K., et al. New paralytic alkaloids, asperparalines A, B and C, from Aspergillus japonicus JV-23. Biosci. Biotechnol. Biochem. 64(1), 111-115 (2000).2. Hirata, K., Kataoka, S., Furutani, S., et al. A fungal metabolite asperparaline a strongly and selectively blocks insect nicotinic acetylcholine receptors: The first report on the mode of action. PLoS One 6(4), e18354 (2011).3. Banks, R.M., Blanchflower, S.E., Everett, J.R., et al. Novel anthelmintic metabolites from an Aspergillus species; the aspergillimides. J. Antibiot. (Tokyo) 50(10), 840-846 (1997).

β-Bag cell peptide是一种提高袋细胞神经元(bag cell neuron)中cAMP水平、并能降低电压依赖性钾电流的神经活性肽。

Mesembranol是一种生物碱，存在于S. tortuosum中，具有神经抑制和类抗焦虑活性。其在大鼠海马切片的theta突发刺激中，以17.16和34.32 nM的浓度使用时，可减少群体尖峰振幅。Mesembranol (50 µM)在斑马鱼幼体的明暗偏好测试中增加中央区域的移动距离，显示出类抗焦虑活性。