aminopterin

Aminopterin (4-Aminofolic acid) 是叶酸的 4-氨基衍生物，是叶酸拮抗剂，具有抗癌和免疫抑制活性，用于研究儿童白血病。它催化叶酸还原为四氢叶酸，竞争性抑制二氢叶酸还原酶，Ki 值为 3.7 pM。

Aminopterin N-hydroxysuccinimide ester is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrof

Aminopterin sodium is an antineoplastic agent with immunosuppressive properties. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effe

10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.

Dihydroaminopterin is a derivative of aminopterin.

10-Methyl-10-deazaaminopterin is a folate analog that shows antitumor activity.

11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.

2'-Fluoroaminopterin is a folic acid antagonist agent.

3'-Fluoroaminopterin is a folic acid antagonist agent.

5,10-Dideazaaminopterin is an antileukemic drug.

11-Thiohomoaminopterin is a 11-thiohomofolic acid analog.

Deazaminopterin is a bioactive chemical.

Tetrahydroxyaminopterin is a bioactive chemical.

Furterene属于氨基喋呤系列的利尿剂，并具有抗醛固酮活性。通过在肾脏的矿物皮质激素受体上拮抗醛固酮，Furterene能够增加钠的排泄同时抑制钾的排泄。

NSC 184692 is a aminopterin-derivative.

Talotrexin (PT523) 是一种 Aminopterin 的类似物，是一种非聚谷氨酸化的经典抗叶酸剂 (antifolate)。 Talotrexin 是一种 RFC(还原型叶酸载体)的特异性抑制剂，可选择性地抑制 RFC 转运。Talotrexin 通过靶向 DHFR 抑制肿瘤生长显示出抗肿瘤活性。