alkin1

ALK-IN-1 是 Brigatinib 的类似物，也是一种常用于抗肿瘤研究的 ALK 抑制剂。

ALK-IN-13 is an ALK inhibitor.

ALK-IN-12 is a highly potent and orally active inhibitor of anaplastic lymphoma kinase (ALK), demonstrating an exceptional IC50 value of 0.18 nM. Additionally, ALK-IN-12 displays inhibitory activity against insulin-like growth factor 1 receptor (IGF1R) and insulin receptor (InsR), with IC50 values of 20.3 nM and 90.6 nM, respectively. Notably, its antitumor effects have been observed, making it a promising compound for targeted cancer therapy.

TRK ALK-IN-1 是一种有效的 TRK 和 ALK 双重抑制剂。TRK ALK-IN-1 在酶促测定中与抗增殖活性非常吻合，对 TRKA、ALKIC50值分别为 2.2、9.3 和 38 nM< sup>WT 和 ALKL1196M。TRK ALK-IN-1具有研究癌症疾病的潜力。