alcohol-preferring

CVT-10216 是可逆的、选择性的醛脱氢酶 2（ALDH-2）抑制剂，IC50为 29 nM。对 ALDH-1的抑制作用较弱，IC50为 1.3 μM。 它可以减少偏爱酒精的大鼠过量饮酒，并表现出抗焦虑作用。

(S)-UFR2709 is a competitive antagonist of the nicotinic acetylcholine receptor (nAChR), exhibiting a greater affinity for α4β2 nAChRs compared to α7 nAChRs. It effectively reduces anxiety and ethanol consumption, as well as ethanol preference, in alcohol-preferring rats. Additionally, (S)-UFR2709 functions as an anxiolytic agent and holds the potential for investigating nicotine addiction.

UFR2709是一种新型的烟碱型乙酰胆碱受体拮抗剂，能够抑制烟碱的奖赏效应，并在酒精偏好的大鼠中降低焦虑和减少乙醇摄入。

(S)-UFR2709 hydrochloride ((S)-UFR2709 HCl) 是一种具有选择性和高效性的 nAChR 拮抗剂，具有抗焦虑活性，抑制 α4β2 nAChR 和 α7 nAChR ，可用于研究尼古丁成瘾。