aglycone

Qingyangshengenin (Cynanchagenin) 是一种孕烷糖苷，是一种分离自Cychuchumot ophyllum(Asclepiadaceae) 的根中的 C21 类固醇糖苷配基。它具有抗癌作用。

Silvestrol aglycone (enantiomer) is a cyclopenta benzofuran core phenol.

Silvestrol aglycone is an analogue of Silvestrol, inhibits protein translation initiation in cancer cells(EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively), with nti-cancer activity.

Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus.

7-Deoxyadriamycinol aglycone is an adriamycin metabolite.

Doramectin aglycone is an acid degradation product of doramectin , a disaccharide-containing anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes, and its acid-catalyzed hydrolysis product doramectin monosaccharide . Doramectin undergoes one round of acid-catalyzed hydrolysis to form doramectin monosaccharide which is then hydrolyzed again to remove the remaining saccharide unit and form doramectin aglycone.

Ivermectin B1a aglycone is an acid degradation product produced by hydrolysis of the disaccharide unit of ivermectin. It can inhibit nematode larval development, but does not cause paralytic activity.

Aloenin aglycone (compound 13) 作为一种NF-κB抑制剂，可从芦荟渗出液中提取。它在抑制TNFα引发的NF-κB转录活性方面表现显著（IC50: 18.7 μM）。当HepG2细胞经10 ng mL TNFα处理时，以10 μM Aloenin aglycone处理能有效下调诱导型一氧化氮合酶（iNOS）及细胞间粘附分子1（ICAM-1）的基因表达。

Daturataturin A aglycone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3775，CAS号为 904665-71-0。

Plucheoside B aglycone 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5385，CAS号为 393862-19-6。

IB-96212aglycone (Compound 2) 是 IB-96212 的水解产物。

Oleuropein aglycone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125057。

Bredinin aglycone 是嘌呤核苷酸类似物，可用于嘌呤核苷酸类似物催化剂的制作效率的检测 。

Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.

Burnettramic acid A aglycone is a fungal metabolite and an aglycone form of burnettramic acid A originally isolated fromA. burnettiithat has anticancer activity.1It is cytotoxic to NS-1 murine myeloma cells but not neonatal foreskin fibroblasts (IC50s = 8.4 and >100 μg ml, respectively). 1.Li, H., Gilchrist, C.L.M., Lacey, H.J., et al.Discovery and heterologous biosynthesis of the burnettramic acids: Rare PKS-NRPS-derived bolaamphiphilic pyrrolizidinediones from an Australian fungus, Aspergillus burnettiiOrg. Lett.21(5)1287-1291(2019)

Momordicoside I aglycone is a natural product

Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.

3'-Ethoxy-5,6-dihydrospinosyn J 17-pseudoaglycone 是一种多杀菌素的衍生物，具有高效的杀虫活性。3'-Ethoxy-5,6-dihydrospinosyn J 17-pseudoaglycone (500mg L) 能够对粘虫、蚜虫和红蜘蛛实现 100% 的致死率。

Methyl hesperidin 是一种血管扩张剂。

Genipin ((+)-Genipin) 是衍生自黄栀果实的天然交联剂，可抑制细胞中的 UCP2 (解偶联蛋白 2)。它有蛋白质调节、抗肿瘤、抗炎症、免疫抑制、抗血栓形成和对海马神经元保护的多种生物活性，可研究 2 型糖尿病。

Asiatic acid (Dammarolic acid) 是在Centella asiatica 中发现的一种五环三萜，有抗炎活性，可诱导黑色素瘤细胞的凋亡，有可能治疗皮肤癌。

Arctigenin ((-)-Arctigenin) 是一种存在于牛蒡中的木脂素，具有抗氧化、抗肿瘤、抗炎和抗病毒活性。它可研究代谢紊乱和中枢神经系统功能障碍。

Liquiritigenin (4',7-Dihydroxyflavanone) 是一种黄烷酮，从甘草中分离得到，是高度选择性的雌激素受体β 激动剂，用于活化 ERE tk-Luc 的 EC50值为36.5 nM。

Friedelinol is a pentacyclic trierpene plant as the free acid or the aglycone for many saponins. Friedelinol can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin.