ache-in-27

AChE-IN-27是一种用于高通量测定的小分子。

AChE-IN-60 (compound 6k) 是一种高效的乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 抑制剂，其IC50值分别为27 nM和43 nM。此化合物同时抑制单胺氧化酶MAO-A和MAO-B，IC50值为353 nM和716 nM。

Graphislactone A is an antioxidant produced by Cephalosporium IFB-E001 and M. olivacea. It exhibits dose-dependent scavenging activity against DPPH radicals and metal ion-dependent hydroxyl radicals in vitro. Graphislactone A reduces peroxidation of human LDL and slows peroxidation of linoleic acid by 4.4-fold. It also inhibits acetylcholinesterase (AChE) with an IC50 value of 27 μM.