T13278
|
Valecobulin hydrochloride
|
Microtubule Associated |
Cytoskeletal Signaling |
|
Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). It is a potent inhibitor of β-tubulin polymerization, and with marked antitumor activity against murine and human solid tumors. |
T4327
|
Prexasertib dihydrochloride
|
S6 Kinase;
Apoptosis;
Chk |
Apoptosis;
MAPK;
Cell Cycle/Checkpoint;
PI3K/Akt/mTOR signaling |
|
Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. |
T4310
|
Prexasertib
|
Apoptosis;
Chk |
Apoptosis;
Cell Cycle/Checkpoint |
|
Prexasertib is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. |
T12823
|
S516
|
Microtubule Associated |
Cytoskeletal Signaling |
|
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity. |
T13278L
|
Valecobulin
|
Others |
Others |
|
Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound. |