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Search Results for "S516"
Targets Recommended: Microtubule Associated

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Cat. No. Product Name Target Signaling Pathways
T13278 Valecobulin hydrochloride

Microtubule Associated Cytoskeletal Signaling
Valecobulin hydrochloride (CKD-516 hydrochloride) is a valine prodrug of S516 and a vascular disrupting agent (VDA). It is a potent inhibitor of β-tubulin polymerization, and with marked antitumor activity against murine and human solid tumors.
T4327 Prexasertib dihydrochloride

S6 Kinase; Apoptosis; Chk Apoptosis; MAPK; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.
T4310 Prexasertib

Apoptosis; Chk Apoptosis; Cell Cycle/Checkpoint
Prexasertib is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.
T12823 S516

Microtubule Associated Cytoskeletal Signaling
S516 is an active CKD-516 metabolite and is a potent inhibitor of tubulin polymerization(IC50 of 4.29 μM), has marked antitumor activity.
T13278L Valecobulin

Others Others
Valecobulin is a potent β-tubulin polymerization inhibitor. Valecobulin is a valine prodrug of (S516) and an avascular disrupting compound.

化合物

Valecobulin hydrochloride
T13278
synonym:
Target: Microtubule Associated
Prexasertib dihydrochloride
T4327
synonym:
Target: S6 Kinase, Apoptosis, Chk
Prexasertib
T4310
synonym:
Target: Apoptosis, Chk
S516
T12823
synonym:
Target: Microtubule Associated
Valecobulin
T13278L
synonym:
Target: Others