Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T17263 | XEN907 | Others | Others |
XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM). | |||
T61379 | Anticancer agent 30 | ||
Anticancer agent 30 (compound 6f-Z) 是一种 3-arylidene-2-oxindole 衍生物,一种选择性CDK2抑制剂,具有强效抗癌活性。 | |||
T5143 | Corynoxine hydrochloride(6877-32-3(free base)) | Autophagy | Autophagy |
Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. | |||
Fr16741 |
Oxindole
2-吲哚酮; 板蓝根; Indolin-2-one |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Oxindole是一种芳族杂环砌块,其衍生物是激酶抑制剂研究中的主要成分。 | |||
T23554 | (Z)-FeCP-oxindole | VEGFR; Others | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
(Z)-FeCP-oxindole 是 VEGFR2 的选择性抑制剂,对人类的 IC50 为 200 nM。 (Z)-FeCP-oxindole 具有抗癌活性。 | |||
T22755 | (E)-FeCP-oxindole | VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
(E)-FeCP-oxindole 是一种 VEGFR2 抑制剂,IC50 为 214 nM。 | |||
T34259 | Rankinidine | ||
Rankinidine, as an oxindole alkaloid, is isolated from Gelsemium rankinii. | |||
T0538 |
3-Methylindolin-2-one
3-Methyloxindole; 3-Methyl-2-oxindole; 3-甲基羟基吲哚 |
Others; Endogenous Metabolite | Metabolism; Others |
3-Methyloxindole 是内源性代谢产物的一种。 | |||
T9853 | STING activator Compound 53 | STING | Immunology/Inflammation |
基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING(人 EC50 185 nM)的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。 | |||
T5S0658 |
Corynoxine
柯诺辛; 柯诺辛碱 |
Autophagy | Autophagy |
Corynoxine 是从大叶钩藤中分离出的一种四环羟吲哚生物碱。它是一种自噬增强剂,可通过Akt/mTOR途径促进 α-突触核蛋白的清除。 |