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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22755 |
(E)-FeCP-oxindole
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
(E)-FeCP-oxindole 是一种 VEGFR2 抑制剂,IC50 为 214 nM。 | |||
T23554 |
(Z)-FeCP-oxindole
|
VEGFR; Others | Angiogenesis; Others; Tyrosine Kinase/Adaptors |
(Z)-FeCP-oxindole 是 VEGFR2 的选择性抑制剂,对人类的 IC50 为 200 nM。 (Z)-FeCP-oxindole 具有抗癌活性。 | |||
T0538 |
3-Methylindolin-2-one
3-Methyloxindole,3-Methyl-2-oxindole,3-甲基羟基吲哚 |
Others; Endogenous Metabolite | Metabolism; Others |
3-Methylindolin-2-one (3-Methyloxindole) 是内源性代谢产物的一种。 | |||
T26126 | Roxindole | ||
Roxindole is an effective autoreceptor-selective dopamine agonist with additional properties as a serotonin reuptake inhibitor and 5-HT1A agonist. It was originally developed for the therapy of schizophrenic syndromes. | |||
T23250 | Roxindole hydrochloride | Others | Others |
Dopamine D2 autoreceptor agonist | |||
T9853 |
STING activator Compound 53
|
STING | Immunology/Inflammation |
基于 oxindole 核心结构的 STING activator Compound 53 在永生化细胞和原代细胞中表现出强大的 STING(人 EC50 185 nM)的靶向功能激活以及与 STING 激活一致的细胞因子诱导指纹。 | |||
T17263 |
XEN907
|
Others | Others |
XEN907 is a novel spiro oxindole NaV1.7 blocker. XEN907 also inhibits hNaV1.7 (IC50: 3 nM). | |||
T61379 | Anticancer agent 30 | ||
Anticancer agent 30 (compound 6f-Z) is a potent anticancer compound. It belongs to the class of 3-arylidene-2-oxindole derivatives and acts as a selective inhibitor of CDK2. Extensive research has demonstrated its significant anticancer activity, making it a promising candidate for cancer treatment [1]. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
Fr16741 |
Oxindole
2-吲哚酮,板蓝根,Indolin-2-one |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Oxindole (Indolin-2-one) 是一种芳族杂环砌块,其衍生物是激酶抑制剂研究中的主要成分。 | |||
T5S0658 |
Corynoxine
柯诺辛,柯诺辛碱 |
Autophagy | Autophagy |
Corynoxine 是从大叶钩藤中分离出的一种四环羟吲哚生物碱。它是一种自噬增强剂,可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。 | |||
TN2938 |
3-Hydroxy-3-acetonyloxindole
|
Others | Others |
3-Hydroxy-3-acetonyloxindole是一种天然产物,属于萝藦科牛奶菜属,其产品编号为 TN2938,CAS号为 33417-17-3。3-Hydroxy-3-acetonyloxindole可用作对照参考。 | |||
T37710 |
5-Hydroxyoxindole
|
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
5-Hydroxyoxindole 是尿酸的一种结构类似物,具有脂质过氧化抑制活性和自由基 DPPH 清除活性,可用于氧化应激介导的疾病的研究。 | |||
T34259 |
Rankinidine
|
||
Rankinidine, as an oxindole alkaloid, is isolated from Gelsemium rankinii. | |||
T5143 | Corynoxine hydrochloride(6877-32-3(free base)) | Autophagy | Autophagy |
Corynoxine hydrochloride(6877-32-3(free base)) 是一种天然羟吲哚生物碱,可在不同的神经元细胞系(包括 N2a 和 SHSY-5Y 细胞)中诱导自噬。 | |||
T75438 | Corynoxine hydrochloride | ||
Corynoxine hydrochloride 是一种从Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂,可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。 |