5 mpep

Incadronate, also known as Cimadronate and YM-175, is a bone resorption inhibitor. Incadronate disodium inhibits macrophage migration to site of inflammation in vivo and proliferation and causes apoptosis in cancer cells in vitro. Incadronate disodium is a bone density conservation, antitumor and anti-inflammatory agent.

M-5MPEP is a mGlu5 antagonist.

5-MPEP is a neutral allosteric site ligand of the metabotropic glutamate receptor subtype 5 (mGlu5), blocking the effects of both the allosteric antagonist MPEP and potentiator CDPPB.

Basimglurant (RG7090; RO4917523) sulfate 是一种可口服、具脑穿透性的选择性 mGluR5 负性变构调节剂，Ki 为 1.4 nM (对 [³H]-ABP688) 和 35.6 nM (对 [³H]-MPEP)。Basimglurant sulfate 可抑制 mGlu5 介导的信号通路及受体组成型活性，调节伏隔核多巴胺水平，具有抗焦虑、类抗抑郁、镇痛和促觉醒作用，并可改变非快速眼动睡眠的 δ 波功率，适用于抑郁症、脆性 X 综合征及焦虑症等研究。