4-thiouridine

4-Thiouridine (4-TU) 是一种光活化核糖核苷类似物，广泛用于RNA 分析。

4-Thiouridine 5’-triphosphate (4-Thio-UTP) tetralithium 作为P2Y2和P2Y4受体的高效激动剂，其对hP2Y2的EC50为35 nM，对hP2Y4的EC50为350 nM。该化合物广泛应用于交联实验以及转录复合物标记研究。

4-Thiouridine 5′-triphosphate (4-Thio-UTP) tetrasodium 作为P2Y2和P2Y4受体的有效激动剂，显示出对hP2Y2的EC50为35 nM，以及对hP2Y4的EC50为350 nM。该化合物适用于交联实验和转录复合物标记研究。

5-Methyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside.

2'-O-Methyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 2'-Modified nucleoside.

2'-beta-C-Methyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 2'-Modified nucleoside.

5-Ethyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside.

5-Methoxy-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside, 5-Modified pyrimidine nucleoside.

2'-Deoxy-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside.

2',3',5'-Tri-O-benzoyl-4-thiouridine is a Nucleoside Derivative - Thio-nucleoside.

Nucleoside Derivatives - Thio-nucleosides, Fluoro-Modified nucleosides, 2'-Modified nucleosides

Nucleoside Derivatives - Thio-nucleosides, 2'-Modified nucleosides, 5-Modified pyrimidine nucleosides

4'-Thiouridine is a Thio-nucleoside.

5-Methyl-4'-thiouridine is a Thio-nucleoside.

2',3',5'-Tri-O-Benzoyl-4'-thiouridine is a Thio-nucleoside.

Nucleoside Derivatives - Thio-nucleosides; 5-Modified pyrimidine nucleosides

Nucleoside Derivatives - 5-Modified pyrimidine nucleosides; Thio-nucleosides; Fluoro-modified nucleosides

5’-O-DMT-Ri can be used in the synthesis of oligoribonucleotides[1]. [1]. Kadokura M. Synthesis of 4-thiouridine, 6-thioinosine, and 6-thioguanosine 3’,5’-O-bisphosphates as donor molecules for RNA ligation and their application to the synthesis of photoactivatable TMG-capped U1 snRNA fragments. J Org Chem. 2000 Aug 25;65(17):5104-13.

4-Thiouracil is a photoactivatable probe designated for site-specific applications in detecting RNA structures and nucleic acid-nucleic acid contacts. Upon illumination with ultraviolet light exceeding 300 nm and in the presence of oxygen, it serves as an energy donor, facilitating the generation of singlet oxygen through triplet-triplet energy transfer. This process enables the highly reactive oxygen species to interact with 4-thiouracil, leading to the formation of uracil and uracil-6-sulfonate; the latter exhibits fluorescence around a wavelength of approximately 390 nm. Additionally, 4-Thiouracil functions as a substrate for T. gondii uracil phosphoribosyltransferase, allowing the synthesis of 4-thiouridine monophosphate for subsequent integration into RNA.