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Targets Recommended: Histone Methyltransferase

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Cat. No. Product Name Target Signaling Pathways
T9575 MRTX9768

Histone Methyltransferase Chromatin/Epigenetic
MRTX-9768 是一种有效的、选择性的、具有口服活性的 PRMT5-MTA 复合体抑制剂,可选择性靶向 MTAP/CDKN2A 缺失的肿瘤。
T36630 MRTX9768 hydrochloride

Others Others
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM)[1].MRTX9768 selectively targets MTAP/CDKN2A-deleted tumors[2][1]. In xenograft studies, oral administration of MRTX9768 demonstrates dose-de...

化合物

MRTX9768
Cat.No: T9575
Synonym:
Target: Histone Methyltransferase
MRTX9768 hydrochloride
Cat.No: T36630
Synonym:
Target: Others
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