10-deacetylbaccatin iii

10-Deacetylbaccatin-III 是一种紫杉醇类似物制剂的中间体，具有抗癌活性。

19-Hydroxy-10-deacetylbaccatin III (compound 13) 是紫杉烷类化合物，显示出潜在的抗肿瘤作用。在 A498 和 NCI-H226 细胞系中，此化合物表现出轻微的细胞毒性效应。研究指出，当浓度为 30 μg mL 时，19-Hydroxy-10-deacetylbaccatin III 对 A498 细胞和 NCI-H226 细胞的抑制率为 16.6% 和 32%。

7-Xylosyl-10-deacetylbaccatin III is a natural product from Taxus brevifolia.

Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2 M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).