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TREM-2 Protein, Human, Recombinant (His) V2

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产品编号 TMPY-01148U

TREM-2 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q9NZC2-1.

TREM-2 Protein, Human, Recombinant (His) V2

一键复制产品信息

产品编号 TMPY-01148U

TREM-2 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q9NZC2-1.

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生物活性	Immobilized Human TREM2, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 2.6 ng/ml determined by ELISA (QC Test). Human TREM2, His Tag captured on CM5 Chip via anti-his antibody can bind Human APOE3, hFc Tag with an affinity constant of 0.41 μM as determined in SPR assay (Biacore T200).
产品描述	TREM-2 Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is Q9NZC2-1.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9NZC2-1
蛋白构建	His19-Ser174
蛋白纯度	> 95% as determined by Tris-Bis PAGE
分子量	18.5 kDa (Predicted); 28-40 kDa (Due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.