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Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 μg | ¥ 550 | 5日内发货 | |
50 μg | ¥ 1,670 | 5日内发货 | |
500 μg | ¥ 13,700 | 5日内发货 | |
1 mg | ¥ 20,500 | 5日内发货 |
生物活性 | Loaded Anti-Human Siglec15 mAb-mFc on AMQ Biosensor, can bind Cynomolgus Siglec-15-His with an affinity constant of 0.30 nM as determined in BLI assay. (Regularly tested) |
产品描述 | Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47. |
种属 | Cynomolgus |
表达系统 | HEK293 Cells |
标签 | C-6xHis |
蛋白编号 | A0A2K5UY47 |
别名 | Siglec-15,CD33L3,Sialic acid-binding Ig-like lectin 15,CD33 antigen-like 3 |
氨基酸序列 | Phe20-Thr263 |
蛋白构建 | Phe20-Thr263 |
蛋白纯度 | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
分子量 | 30-40 KDa (reducing condition) |
内毒素 | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
缓冲液 | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 150 mMNaCl, 0.3% Chaps, 5% Trehalose, pH 7.4. |
复溶方法 | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
存储 | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts. |
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