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Siglec-15 Protein, Cynomolgus, Recombinant (His)

产品编号 TMPJ-00434

Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47.

Siglec-15 Protein, Cynomolgus, Recombinant (His)

Siglec-15 Protein, Cynomolgus, Recombinant (His)

产品编号 TMPJ-00434
Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47.
规格价格库存数量
10 μg¥ 5505日内发货
50 μg¥ 1,6705日内发货
500 μg¥ 13,7005日内发货
1 mg¥ 20,5005日内发货
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生物活性

生物活性
Loaded Anti-Human Siglec15 mAb-mFc on AMQ Biosensor, can bind Cynomolgus Siglec-15-His with an affinity constant of 0.30 nM as determined in BLI assay. (Regularly tested)
产品描述
Siglec-15 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is A0A2K5UY47.
种属
Cynomolgus
表达系统
HEK293 Cells
标签C-6xHis
蛋白编号A0A2K5UY47
别名
Siglec-15,CD33L3,Sialic acid-binding Ig-like lectin 15,CD33 antigen-like 3
氨基酸序列
Phe20-Thr263
蛋白构建
Phe20-Thr263
蛋白纯度
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量30-40 KDa (reducing condition)
内毒素< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, 150 mMNaCl, 0.3% Chaps, 5% Trehalose, pH 7.4.
复溶方法
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储
Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景
Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO−-terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain (Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts.

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