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SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)

SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)

产品编号 TMPY-02820
别名: SDF1, chemokine (C-X-C motif) ligand 12, IRH, SCYB12, TPAR1, SDF-1, TLSF, PBSF

SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.

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SDF-1/CXCL12 Protein, Human, Recombinant (isoform a)
规格 价格/CNY 货期 数量
20 μg ¥ 1,350 现货
100 μg ¥ 3,930 5日内发货
200 μg ¥ 6,670 5日内发货
500 μg ¥ 13,380 5日内发货
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产品目录号及名称: SDF-1/CXCL12 Protein, Human, Recombinant (isoform a) (TMPY-02820)
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生物活性 Testing in progress
产品描述 SDF-1 Protein, Human, Recombinant (isoform a) is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is P48061-2.
种属 Human
表达系统 E. coli
标签 Tag Free
蛋白编号 P48061-2
别名 SDF1, chemokine (C-X-C motif) ligand 12, IRH, SCYB12, TPAR1, SDF-1, TLSF, PBSF
蛋白构建 The Human CXCL12 isoform alpha (P48061-2) (Lys 22-Lys 89) was expressed and purified.
蛋白纯度 ≥ 95 % as determined by SDS-PAGE

TargetMol

分子量 8 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms from a single gene that encodes two splice variants, SDF1α and SDF1β, which are identical except for the four residues present in the C-terminus of SDF1β but absent from SDF1α. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184). The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription. CXCL12 and CXCR4 that have been widely characterized in peripheral tissues and delineate their main functions in the CNS. Extensive evidence supports CXCL12 as a key regulator for early development of the CNS. In the mature CNS, CXCL12 modulates neurotransmission, neurotoxicity and neuroglial interactions. CXCL12 has crucial roles in the formation of multiple organ systems during embryogenesis and in the regulation of bone marrow haematopoiesis and immune function in the postnatal organism. Although considered an important factor in normal bone metabolism, recent studies implicate CXCL12 in the pathogenesis of several diseases involving the skeleton, including rheumatoid arthritis and cancers that metastasize to bone. The CXCL12/CXCR4 axis is involved in tumor progression, angiogenesis, metastasis, and survival. Pathologically enhanced CXCL12 signaling may promote the formation of new vessels through recruiting circulating endothelial progenitor cells or directly enhancing the migration/growth of endothelial cells. Therefore, CXCL12 signaling represents an important mechanism that regulates brain tumor angiogenesis/vasculogenesis and may provide potential targets for anti-angiogenic therapy in malignant gliomas.

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Keywords

SDF-1/CXCL12 Protein, Human, Recombinant (isoform a) SCYB 12 SDF1 chemokine (C-X-C motif) ligand 12 IRH SCYB12 TPAR1 SDF-1 TPAR 1 TPAR-1 TLSF SDF 1 SCYB-12 PBSF recombinant recombinant-proteins proteins protein

 

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