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SCF Protein, Mouse, Recombinant (His), Biotinylated

产品编号 TMPY-05135

别名: Con, SLF, SF, Mgf, Gb, Clo, KIT ligand, Sl, Kitlg, SCF

SCF Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.

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SCF Protein, Mouse, Recombinant (His), Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 2,440		5日内发货
100 μg	￥ 5,810		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	SCF Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.

种属	Mouse
表达系统	Baculovirus Insect Cells
标签	C-His
蛋白编号	P20826-1
别名	Con, SLF, SF, Mgf, Gb, Clo, KIT ligand, Sl, Kitlg, SCF
蛋白构建	The Kitlg (P20826-1) (Met1-Ala189) was expressed with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
蛋白纯度	> 80 % as determined by SDS-PAGE.
分子量	19.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing Sterile PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Similar to Kit ligand precursor (C-kit ligand), also known as Stem cell factor (SCF), Mast cell growth factor (MGF), or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. SCF/C-kit ligand stimulates the proliferation of mast cells. This protein can augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It may act synergistically with other cytokines, probably interleukins SCF/C-kit ligand is the ligand for the tyrosine kinase receptor c-kit, which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro, SCF/C-kit ligand synergizes with other growth factors, such as granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor, and interleukin-3 to stimulate the proliferation and differentiation of cells of the lymphoid, myeloid, erythroid, and megakaryocytic lineages. In vivo, SCF/C-kit also synergizes with other growth factors and has been shown to enhance the mobilization of peripheral blood progenitor cells in combination with G-CSF. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.

参考文献

1. McNiece IK,et al. (1995) Stem cell factor. J Leukoc Biol. 58(1): 14-22. 2. Besmer P,et al. (1993) The kit-ligand (steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis. Dev Suppl. 1993:125-37. 3. Mekori YA,et al. (1993) IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand. J Immunol. 151(7): 3775-84.

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Keywords

SCF Protein, Mouse, Recombinant (His), Biotinylated Con SLF SF Mgf Gb Clo KIT ligand Sl Kitlg SCF recombinant recombinant-proteins proteins protein

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