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PTPN12 Protein, Human, Recombinant

PTPN12 Protein, Human, Recombinant

产品编号 TMPY-03548
别名: protein tyrosine phosphatase, non-receptor type 12, PTP-PEST, PTPG1

PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1.

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PTPN12 Protein, Human, Recombinant
规格 价格/CNY 货期 数量
100 μg ¥ 4,460 5日内发货
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千万补贴 助力科研
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产品目录号及名称: PTPN12 Protein, Human, Recombinant (TMPY-03548)
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生物活性
技术参数
产品性质
参考文献
生物活性 Measured by its ability to dephosphorylate a tyrosine residue in a peptide containing the EGFR Y992 phosphorylation site . The specific activity is >20 µmol/min/mg.
产品描述 PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1.
种属 Human
表达系统 Baculovirus Insect Cells
标签 Tag Free
蛋白编号 AAA36529.1
别名 protein tyrosine phosphatase, non-receptor type 12, PTP-PEST, PTPG1
蛋白构建 The Human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed and purified with two additional amino acids (Gly & Pro) at the N-terminus.
蛋白纯度 > 85 % as determined by SDS-PAGE
分子量 41.8 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store the product under sterile conditions at -20℃ to -80℃. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. PTPN12 was shown to interact with, and dephosphorylate, various cytoskeleton and cell adhesion molecules, such as p13 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.

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Keywords

PTPN12 Protein, Human, Recombinant PTPG-1 protein tyrosine phosphatase, non-receptor type 12 PTP-PEST PTPG 1 PTPG1 recombinant recombinant-proteins proteins protein

 

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