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PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST)

产品编号 TMPY-03486

别名: PTPG1, protein tyrosine phosphatase, non-receptor type 12, PTP-PEST

PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.4 kDa and the accession number is AAA36529.1.

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PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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参考文献

生物活性	Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate. The specific activity is > 15 μmoles/min/mg.
产品描述	PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.4 kDa and the accession number is AAA36529.1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	His, GST
蛋白编号	AAA36529.1
别名	PTPG1, protein tyrosine phosphatase, non-receptor type 12, PTP-PEST
蛋白构建	The Human PTPN12 (AAA36529.1) (Met1-Gln355) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	69.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, 10% gly, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN12 contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. PTPN12 was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. PTPN12 was shown to interact with, and dephosphorylate, various cytoskeleton and cell adhesion molecules, such as p13 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.

参考文献

1. Garton AJ. et al., 1997, Oncogene. 15 (8): 877-85. 2. Lin Yi. et al., 2003, Am J Physiol Heart Circ. 285 (2): H710-21. 3. Takekawa M. et al., 1994, FEBS Lett. 339 (3): 222-8.

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Keywords

PTPN12 Protein, Human, Recombinant (aa 1-355, His & GST) PTPG1 PTPG 1 PTPG-1 protein tyrosine phosphatase, non-receptor type 12 PTP-PEST recombinant recombinant-proteins proteins protein

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