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CXADR/CAR Protein, Mouse, Recombinant (hFc)

CXADR/CAR Protein, Mouse, Recombinant (hFc)

产品编号 TMPJ-00237
别名: CVB3 BP, Cxadr, CAR, Coxsackievirus and adenovirus receptor homolog

CXADR/CAR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P97792.

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CXADR/CAR Protein, Mouse, Recombinant (hFc)
规格 价格/CNY 货期 数量
10 μg ¥ 820 5日内发货
50 μg ¥ 2,480 5日内发货
500 μg ¥ 12,100 5日内发货
1 mg ¥ 17,400 5日内发货
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产品目录号及名称: CXADR/CAR Protein, Mouse, Recombinant (hFc) (TMPJ-00237)
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产品描述 CXADR/CAR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 50-70 KDa and the accession number is P97792.
种属 Mouse
表达系统 HEK293 Cells
标签 C-hFc
蛋白编号 P97792
别名 CVB3 BP, Cxadr, CAR, Coxsackievirus and adenovirus receptor homolog
氨基酸序列 Leu20-Gly237
蛋白构建 Leu20-Gly237
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 50-70 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Coxsackievirus and adenovirus receptor homolog(CAR), also known as CXADR, is a type I transmembrane glycoprotein that belongs to the CTX family of the Ig superfamily. CXADR has monomer subunit that interacts with LNX, BAIAP1, DLG4, PRKCABP, TJP1 and CTNNB1. It also interacts with MPDZ and JAML. CXADR composed of of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. CXADR also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

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Keywords

CXADR/CAR Protein, Mouse, Recombinant (hFc) CVB3 BP Cxadr CAR Coxsackievirus and adenovirus receptor homolog recombinant recombinant-proteins proteins protein

 

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