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Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated

Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated

产品编号 TMPJ-00310
别名: Nectin-4, PVRL4, LNIR, PRR4, Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4

Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 40-50 KDa and the accession number is Q96NY8.

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Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated
规格 价格/CNY 货期 数量
20 μg ¥ 2,260 5日内发货
100 μg ¥ 6,130 5日内发货
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产品目录号及名称: Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated (TMPJ-00310)
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生物活性
技术参数
产品性质
生物活性 1. Loaded Biotinylated Human Nectin-4-His-Avi on SA Biosensor, can bind Anti-Human Nectin-4 mAb-mFc with an affinity constant of 1 <10-3 nM as determined in BLI assay. (Regularly tested) 2. Immobilized Human Nectin-4-His-Avi at 2μg/ml (100 μl/well) can bind Anti-Human Nectin-4 mAb-mFc. The ED50 of Anti-Human Nectin-4 mAb-mFc is 12.28 ng/ml. (Regularly tested)
产品描述 Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 40-50 KDa and the accession number is Q96NY8.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis-Avi
蛋白编号 Q96NY8
别名 Nectin-4, PVRL4, LNIR, PRR4, Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4
氨基酸序列 Gly32-Val351
蛋白构建 Gly32-Val351
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 40-50 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Nectin-4 (PVRL4) is a type I transmembrane glycoprotein which belongs to the nectin family of Ig superfamily proteins. It contains two Ig-like C2-type domains and one Ig-like V-type domain. PVRL4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with nectin-1. It does not act as receptor for alpha-herpesvirus entry into cells. It is predominantly expressed in placenta, the embryo and breast carcinoma. But it is not detected in normal breast epithelium. The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder.

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Keywords

Nectin-4 Protein, Human, Recombinant (His & Avi), Biotinylated Nectin-4 PVRL 4 PVRL4 LNIR PRR4 Ig superfamily receptor LNIR PRR-4 PRR 4 Poliovirus receptor-related protein 4 PVRL-4 recombinant recombinant-proteins proteins protein

 

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