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IL-17C Protein, Human, Recombinant (His)

IL-17C Protein, Human, Recombinant (His)

产品编号 TMPJ-00078
别名: CX2, IL-17C, interleukin-17C, IL17C, IL-17CMGC126884, Cytokine CX2, interleukin 17C

IL-17C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is Q9P0M4.

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IL-17C Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
10 μg ¥ 580 5日内发货
50 μg ¥ 1,770 5日内发货
500 μg ¥ 15,400 5日内发货
1 mg ¥ 23,100 5日内发货
夏季3重特惠
药物设计专题培训
Chloroquine限时半价
产品目录号及名称: IL-17C Protein, Human, Recombinant (His) (TMPJ-00078)
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产品性质
产品描述 IL-17C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 19 KDa and the accession number is Q9P0M4.
种属 Human
表达系统 HEK293 Cells
标签 C-6xHis
蛋白编号 Q9P0M4
别名 CX2, IL-17C, interleukin-17C, IL17C, IL-17CMGC126884, Cytokine CX2, interleukin 17C
氨基酸序列 His19-Val197
蛋白构建 His19-Val197
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 19 KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Interleukin 17C (IL 17C) is a 15 20 kDa glycosylated cytokine that plays an important role in mucosal immunity and chronic inflammation. IL 17C binds to IL 17 RE with high affinity and to IL 17 RA with low affinity. These two receptor chains can associate into a heterodimeric receptor for IL 17C. IL 17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is up regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). IL 17 RE is reciprocally down regulated in psoriatic lesions. The interaction of IL 17C with IL 17 RE promotes mucosal immunity through the induction of anti bacterial peptides and pro inflammatory cytokines and chemokines. IL 17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis. IL 17C is additionally up regulated in Th17 cell dependent autoimmunity. In this setting, it exacerbates disease severity by inducing Th17 cell production of IL 17A, IL 17F, IL 22, CCR6, and CCL20.

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Keywords

IL-17C Protein, Human, Recombinant (His) IL-17CMGC 126884 CX 2 CX2 IL-17C interleukin-17C IL17C IL-17CMGC126884 CX-2 Cytokine CX2 IL-17CMGC-126884 interleukin 17C recombinant recombinant-proteins proteins protein

 

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