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顶部产品介绍化学信息储存和溶解信息计算器技术支持

B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)

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货号 TMPK-00192

别名 LICOS, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP1B7-like protein Gl50, B7RP-1, B7RP1, B7-H2B7-related protein 1, B7-H2, B7H2

B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144.

B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)
其他形式的 “B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)”:
B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi), Biotinylated
B7-H2/ICOSLG Protein, Cynomolgus, Recombinant (His)
B7-H2/ICOSLG Protein, Mouse, Recombinant (His & hFc)
B7-H2/ICOSLG Protein, Human, Recombinant (His)
ICOS ligand Protein, Human, Recombinant (hFc)
B7-H2/ICOSLG Protein, Mouse, Recombinant (His)
B7-H2/ICOSLG Protein, Human, Recombinant (His), Biotinylated
B7-H2/ICOSLG Protein, Human, Recombinant

B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi)

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货号 TMPK-00192 别名 LICOS, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP1B7-like protein Gl50, B7RP-1, B7RP1, B7-H2B7-related protein 1, B7-H2, B7H2

B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144.

规格价格库存数量
5 μg
¥ 198
6-8日内发货
10 μg
¥ 319
6-8日内发货
20 μg
¥ 497
5日内发货
50 μg
¥ 973
5日内发货
100 μg
¥ 1,620
5日内发货
200 μg
¥ 2,930
5日内发货
500 μg
¥ 6,520
5日内发货
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产品介绍

生物活性
产品描述
B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. B7-H2/ICOSLG Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 29.5 kDa and the accession number is O75144.
生物活性
1. Immobilized Human B7-H2, His Tag at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Human ICOS, hFc Tag with the EC50 of 23.6ng/ml determined by ELISA. 2. Human ICOS, hFc Tag (Q50A) captured on CM5 Chip via Protein A can bind Human B7-H2, His Tag with an affinity constant of 41.98 nM as determined in SPR assay.
研究背景
B7-H2, also known as B7-related protein (B7RP1), ICOS Ligand, and CD275, is an approximately 60 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is a ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells.
种属
Human
表达系统
HEK293 Cells
标签C-His-Avi
蛋白编号O75144
蛋白构建Asp19-Ser258
蛋白纯度
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状Lyophilized powder
缓冲液Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名LICOS, ICOSLG, ICOS-L, ICOSL, ICOS ligand, GL50, CD275, B7RP1B7-like protein Gl50, B7RP-1, B7RP1, B7-H2B7-related protein 1, B7-H2, B7H2
内毒素< 1 EU/μg by the LAL method.
化学信息
分子量29.5 kDa (predicted). Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
储存&溶解度
运输方式In general, Lyophilized powders are shipping with blue ice.
存储It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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技术支持

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关键词

GL-50GL 50CD-275CD 275
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