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HMGB1 Protein, Human, Recombinant (His)

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产品编号 TMPY-01848U

HMGB1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is P09429-1.

HMGB1 Protein, Human, Recombinant (His)

一键复制产品信息

产品编号 TMPY-01848U

HMGB1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is P09429-1.

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产品信息

生物活性	Human AGER, His Tag immobilized on CM5 Chip can bind Human HMGB1, His Tag with an affinity constant of 0.19 μM as determined in SPR assay (Biacore T200).
产品描述	HMGB1 Protein, Human, Recombinant (His) is expressed in HEK293 Cells. The accession number is P09429-1.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P09429-1
蛋白构建	Met1-Glu215
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
分子量	26 kDa (Predicted); 30-35 kDa (Due to glycosylation)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	High-mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that promotes inflammation when released extracellularly after cellular activation, stress, damage or death. HMGB1 operates as one of the most intriguing molecules in inflammatory disorders via recently elucidated signal and molecular transport mechanisms. Treatments based on antagonists specifically targeting extracellular HMGB1 have generated encouraging results in a wide number of experimental models of infectious and sterile inflammation.