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GM-CSFR alpha Protein, Human, Recombinant (His) V2

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产品编号 TMPY-01065U

GM-CSFR alpha Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15509.

GM-CSFR alpha Protein, Human, Recombinant (His) V2

一键复制产品信息

产品编号 TMPY-01065U

GM-CSFR alpha Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15509.

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产品信息

生物活性	Measured by its ability to inhibit GM-CSF-dependent proliferation of TF‑1 human erythroleukemic cells.The ED50 for this effect is 0.5-2 μg/ml. (QC verified)
产品描述	GM-CSFR alpha Protein, Human, Recombinant (His) V2 is expressed in HEK293 Cells. The accession number is P15509.
种属	Human
表达系统	HEK293 Cells
标签	C-6xHis
蛋白编号	P15509
别名	集落刺激因子,SMDP4,GMR,GM-CSF-R-α,GM-CSF-R-alpha,GMCSFR,GM-CSF Receptor α Protein,CSF2RY,CSF2RX,CSF2RAY,CSF2RAX,CSF2R,colony stimulating factor 2 receptor, α, low-affinity (granulocyte-macrophage),colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage),CDw116,CD116
蛋白构建	Glu23-Gly320
蛋白纯度	> 95% as determined by SDS-PAGE
分子量	35.5 kDa (Predicted); 60 kDa (Reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit α (CSF2RA) is a single-pass type I membrane protein which belongs to the type I cytokine receptor family of Type 5 subfamily. The CSF2RA gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes with some of the isoforms being membrane-bound and others being soluble. CSF2RA is a low affinity receptor for granulocyte-macrophage colony-stimulating factor. CSF2RA transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4).