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GDNF Protein, Rat, Recombinant (His)

产品编号 TMPY-02911

别名: glial cell derived neurotrophic factor, 胶质细胞生长因子

GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is Q07731-1.

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GDNF Protein, Rat, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,430		5日内发货

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参考文献

生物活性	1. Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is typically 10-50 ng/mL in the presence of Recombinant Rat GFR alpha‑1/GDNF R alpha‑1 His Chimera. 2. Immobilized rat His-GDNF (78-211) at 10 μg/ml (100 μl/well) can bind rat GFRA1-Fc , The EC50 of rat GFRA1-Fc is 20-46.6 ng/ml.
产品描述	GDNF Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is Q07731-1.

种属	Rat
表达系统	Baculovirus Insect Cells
标签	N-His
蛋白编号	Q07731-1
别名	glial cell derived neurotrophic factor, 胶质细胞生长因子
蛋白构建	The mature form of Rat GDNF (Q07731-1) (Ser78-Ile211) was expressed,with a polyhistide tag at the N-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	17.1 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris, 500 mM NaCl, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF), neurturin (NRTN), artemin (ARTN), and persephin (PSPN). It has been found that GFLs play a role in a number of biological processes including cell survival, neurite outgrowth, cell differentiation and cell migration. As the founding member, GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. It has been shown that GDNF results in two Parkinson's disease clinical trial and in a number of animal trials. It has been taken as a potent survival factor for central motoneurons.

参考文献

1. Oppenheim RW,et al. (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature. 373 (6512): 344-6. 2. Tomac A,et al. (1995) Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373 (6512): 335-9. 3. Schindelhauer D,et al. (1996) The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1. 4. Genomics. 28 (3): 605-7.Carnicella S,et al. (2008) GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci . 105 (23): 8114-9.

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Keywords

GDNF Protein, Rat, Recombinant (His) glial cell derived neurotrophic factor 胶质细胞生长因子 recombinant recombinant-proteins proteins protein

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