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Fractalkine Protein, Canine, Recombinant

产品编号 TMPY-03898

别名: chemokine (C-X3-C motif) ligand 1

Fractalkine Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.2 kDa and the accession number is H1ADY9.

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Fractalkine Protein, Canine, Recombinant

规格	价格/CNY		货期	数量
50 μg	￥ 2,940		5日内发货

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生物活性	Testing in progress
产品描述	Fractalkine Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.2 kDa and the accession number is H1ADY9.

种属	Canine
表达系统	HEK293 Cells
标签	Tag Free
蛋白编号	H1ADY9
别名	chemokine (C-X3-C motif) ligand 1
蛋白构建	The canine CX3CL1 (H1ADY9) (Met1-Arg379) was expressed with six amino acids (LEVLFQ) at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	38.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.

参考文献

1. Imai T, et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91(4): 521-30. 2. Papadopoulos EJ, et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 29 (8): 2551-9. 3. Umehara H, et al. (2004) Fractalkine in vascular biology: from basic research to clinical disease". Arterioscler. Thromb Vasc Biol. 24 (1): 34-40.

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Keywords

Fractalkine Protein, Canine, Recombinant chemokine (C-X3-C motif) ligand 1 recombinant recombinant-proteins proteins protein

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