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Fractalkine Protein, Human, Recombinant (His)

产品编号 TMPY-00737

别名: CXC3, neurotactin, ABCD-3, CXC3C, chemokine (C-X3-C motif) ligand 1, fractalkine, C3Xkine, NTT, NTN, SCYD1

Fractalkine Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is A0N0N7.

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Fractalkine Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 1,950		5日内发货
1 mg	￥ 19,500		5日内发货

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生物活性	Testing in progress
产品描述	Fractalkine Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35 kDa and the accession number is A0N0N7.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	A0N0N7
别名	CXC3, neurotactin, ABCD-3, CXC3C, chemokine (C-X3-C motif) ligand 1, fractalkine, C3Xkine, NTT, NTN, SCYD1
蛋白构建	Human CX3CL1 (NP_002987.1) extracellular domain (Met 1-Arg 339) with a C-terminal polyhistidine tag
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	35 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.

参考文献

1. Imai T, et al. (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell. 91(4): 521-30. 2. Papadopoulos EJ, et al. (1999) Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation. Eur J Immunol. 29 (8): 2551-9. 3. Umehara H, et al. (2004) Fractalkine in vascular biology: from basic research to clinical disease". Arterioscler. Thromb Vasc Biol. 24 (1): 34-40.

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Keywords

Fractalkine Protein, Human, Recombinant (His) CXC3 CXC 3 neurotactin ABCD 3 ABCD-3 CXC3C chemokine (C-X3-C motif) ligand 1 CXC-3 fractalkine C3Xkine ABCD3 NTT SCYD-1 SCYD 1 NTN SCYD1 recombinant recombinant-proteins proteins protein

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