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CD19 Protein, Human, Recombinant (CHO, hFc)

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产品编号 TMPY-05427U

CD19 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is P15391.

CD19 Protein, Human, Recombinant (CHO, hFc)

一键复制产品信息

产品编号 TMPY-05427U

CD19 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is P15391.

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重组蛋白用户指南

产品信息

生物活性	Immobilized Human FMC63 at 2 μg/ml (100 μl/well) can bind Human CD19-Fc. The ED50 of Recombinant Human CD19-Fc is 55.28 ng/ml. Loaded Anti-Human CD19 mAb-Fc on AMC Biosensor, can bind Human CD19-FC with an affinity constant of 2.72 nM as determined in BLI assay.
产品描述	CD19 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is P15391.
种属	Human
表达系统	CHO Cells
标签	C-Fc
蛋白编号	P15391
蛋白构建	Pro20-Lys291
蛋白纯度	> 95% as determined by SDS-PAGE
分子量	57.3 kDa (Predicted); 80-95 kDa (Reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.