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Calnexin Protein, Human, Recombinant (hFc)

产品编号 TMPY-03112

别名: P90, calnexin, CNX, IP90

Calnexin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.4 kDa and the accession number is P27824.

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Calnexin Protein, Human, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 2,530		5日内发货

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生物活性	Testing in progress
产品描述	Calnexin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.4 kDa and the accession number is P27824.

种属	Human
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	P27824
别名	P90, calnexin, CNX, IP90
蛋白构建	The Human CANX (P27824) (Met1-Pro481) was expressed, fused with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	79.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Calnexin is a calcium-binding protein that belongs to the calreticulin family. It interacts with newly synthesized glycoproteins in the endoplasmic reticulum. Calnexin seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.

参考文献

1. Rajagopalan S,et al.(1994) Retention of unassembled components of integral membrane proteins by Calnexin(CANX). Science. 263(5145):387-90. 2. Lenter M,et al.(1994) The integrin chains beta 1 and alpha 6 associate with the chaperone Calnexin(CANX) prior to integrin assembly. J Biol Chem. 269(16):12263-8. 3. Pind S,et al.(1994) Retention of unassembled components of integral membrane proteins by Calnexin(CANX). Science. 263(5145):387-90.

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Keywords

Calnexin Protein, Human, Recombinant (hFc) P-90 P90 IP-90 calnexin IP 90 CNX IP90 P 90 recombinant recombinant-proteins proteins protein

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