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Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated

产品编号 TMPY-05759

别名: RPRGL3, ANX5, HEL-S-7, annexin A5, PP4, ENX2

Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758.

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Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated

规格	价格/CNY		货期	数量
20 μg	￥ 1,950		5日内发货
100 μg	￥ 4,620		5日内发货

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生物活性	Testing in progress
产品描述	Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 35.9 kDa and the accession number is P08758.

种属	Human
表达系统	E. coli
标签	Tag Free
蛋白编号	P08758
别名	RPRGL3, ANX5, HEL-S-7, annexin A5, PP4, ENX2
蛋白构建	The Human ANXA5 (P08758) (Met1-Asp320) was expressed and purified. The purified protein was biotinylated in vitro.
蛋白纯度	> 90 % as determined by SDS-PAGE.
分子量	35.9 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. The association found between the maternal carriage of the M2/ANXA5 haplotype and an elevated risk of IUGR and/or PE supports the hypothesis that carrier status of this haplotype and the consequently reduced placental ANXA5 expression might be responsible, at least partially, for the onset of these gestational vascular complications. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-for-gestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis.

参考文献

1. Cederholm A, et al. (2007) Annexin A5 as a novel player in prevention of atherothrombosis in SLE and in the general population. Ann N Y Acad Sci. 1108: 96-103. 2. Schlaepfer DD, et al. (1992) Inhibition of Protein Kinase C by AnnexinⅤ. Biochemistry. 31: 1886-91. 3. Vermes I, et al. (1995) A novel assay for apoptosis-flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin Ⅴ. J Immunol Methods. 184 (1): 39-51.

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Keywords

Annexin V/ANXA5 Protein, Human, Recombinant, Biotinylated RPRGL3 ANX5 ANX 5 HEL-S-7 ANX-5 annexin A5 RPRGL 3 ENX 2 PP4 PP 4 ENX-2 ENX2 PP-4 RPRGL-3 recombinant recombinant-proteins proteins protein

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