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ACVR2A Protein, Human, Recombinant (hFc & His)

ACVR2A Protein, Human, Recombinant (hFc & His)

产品编号 TMPJ-00315
别名: ACTR-IIA, Activin Receptor Type IIA, ACTRIIA, Activin Receptor Type-2A, ACVR2, ACVR2A

Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

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ACVR2A Protein, Human, Recombinant (hFc & His)
规格 价格/CNY 货期 数量
10 μg ¥ 380 5日内发货
50 μg ¥ 1,170 5日内发货
500 μg ¥ 5,130 5日内发货
1 mg ¥ 6,720 5日内发货
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产品目录号及名称: ACVR2A Protein, Human, Recombinant (hFc & His) (TMPJ-00315)
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生物活性
技术参数
产品性质
生物活性 Immobilized Human INHBC-His at 10μg/ml (100 μl/well) can bind Human ACVR2A-Fc-His . The ED50 of Recombinant Human ACVR2A-Fc-His  is 2-8 ug/ml. (Regularly tested)
产品描述 Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
种属 Human
表达系统 HEK293 Cells
标签 C-hFc-6xHis
蛋白编号 P27037
别名 ACTR-IIA, Activin Receptor Type IIA, ACTRIIA, Activin Receptor Type-2A, ACVR2, ACVR2A
氨基酸序列 Ala20-Pro134
蛋白构建 Ala20-Pro134
蛋白纯度 Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
分子量 60KDa&40KDa (reducing condition)
内毒素 < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.4.
复溶方法 Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

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Keywords

ACVR2A Protein, Human, Recombinant (hFc & His) ACTR-IIA ACVR-2 Activin Receptor Type IIA ACVR 2 ACTRIIA Activin Receptor Type-2A ACVR2 ACVR2A recombinant recombinant-proteins proteins protein

 

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