Name: Zevaquenabant
Brand: TargetMol
SKU: T39410
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 10,600

6-8周

生物活性

产品描述	Zevaquenabant ((S)-MRI-1867), a dual cannabinoid CB1 receptor and inducible NOS (iNOS) antagonist, is orally bioavailable and peripherally restricted. It effectively mitigates obesity-induced chronic kidney disease (CKD).
体外活性	Zevaquenabant can simultaneously inhibit CB1 receptors and iNOS in peripheral organs[1].
体内活性	Zevaquenabant (3 mg/kg; p.o.; for 28 days) improves renal morphological and functional parameters in diet-induced obese mice[1]. Animal Model: 6-week-old male C57Bl/6J mice (diet-induced obesity)[1]Dosage: 3 mg/kg Administration: P.o.; for 28 days Result: Improved kidney morphology and function in diet-induced obese mice.
别名	(S)-MRI-1867

化学信息

分子量	547.98
分子式	C₂₅H₂₁ClF₃N₅O₂S
CAS No.	1998760-00-1
Smiles	CC(=N)N=C(NS(=O)(=O)c1ccc(cc1)C(F)(F)F)N1C[C@@H](C(=N1)c1ccc(Cl)cc1)c1ccccc1 \|w:3.2,c:23\|