VPM-p15 is an optimized peptide agonist targeting the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). It exhibits significantly higher affinity for GPR64 compared to the original p15 peptide. VPM-p15 significantly elevates cAMP levels, activating GPR64 and triggering downstream Gs, Gq, and G12/13 signaling pathways. This compound can be utilized in research focused on activation mechanisms of adhesion GPCR family members.