Name: Timigutuzumab
Brand: TargetMol
SKU: T76977
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

生物活性

产品描述	Timigutuzumab (GEXMab73) is a glyco-optimized monoclonal antibody targeting the human epidermal growth factor receptor 2 (ErbB2/HER2). Through glyco-engineering (typically afucosylation), the antibody's Fc region exhibits enhanced binding affinity for the FcγRIIIa receptors on immune effector cells, such as natural killer (NK) cells. This optimization significantly boosts Antibody-Dependent Cell-mediated Cytotoxicity (ADCC), enabling potent tumor cell lysis even in cases with low HER2 expression levels. Timigutuzumab is designed to overcome resistance to conventional anti-HER2 therapies and provide an improved therapeutic option for solid tumors.
体外活性	Timigutuzumab (GEXMab73) 通过糖基化优化增强了对 Fcγ 受体的亲和力，显著提升了针对 HER2 阳性细胞的 ADCC 活性。相比未经优化的抗体，它能在较低浓度下实现更高效的肿瘤细胞清除 [1]。
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	P04626
靶点	ErbB2

化学信息

CAS No.

1665274-14-5

储存&溶解度

存储	Lyophilized powder: -20~-80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Timigutuzumab