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Tiliquinol

Name: Tiliquinol
Brand: TargetMol
SKU: T64352
Price: 120 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 甲羟喹, NSC 130828

货号 T64352Cas号 5541-67-3 一键复制产品信息纯度: 99.74%

很棒

Tiliquinol (NSC-130828) 是一种与tibroquinol经常联用、具有抗阿米巴特性的非吸收性腔内药物，通常用于研究和调查阿米巴性肝脓肿。

Tiliquinol

一键复制产品信息

很棒

纯度: 99.74%

货号 T64352Cas号 5541-67-3

别名 甲羟喹, NSC 130828

Tiliquinol (NSC-130828) 是一种与tibroquinol经常联用、具有抗阿米巴特性的非吸收性腔内药物，通常用于研究和调查阿米巴性肝脓肿。

规格	价格	库存
5 mg	¥ 120	现货
10 mg	¥ 167	现货
25 mg	¥ 277	现货
50 mg	¥ 405	现货
100 mg	¥ 592	现货
500 mg	¥ 1,470	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.74%

颜色: 黄色

性状: Solid

资源下载: COA HNMR LCMS产品操作手册

产品介绍

Tiliquinol AI Summary

Tiliquinol exhibits a broad spectrum of bioactivities across various assays and models. It has demonstrated the ability to inhibit ROR gamma transcriptional activity, delay death of malarial parasite plastid, support Schwann cell viability, induce DNA re-replication in various cell lines, inhibit human tyrosyl-DNA phosphodiesterase 1, and block entry of both Marburg and Ebola viruses. Additionally, it shows potency as a gametocytocidal compound. Despite its wide-ranging pharmacological effects, it exhibits relatively low potency in assays targeting receptors like DRD1, SLC6A2, and HRH3, as well as enzymes such as ACHE, MAOA, and PTGS1. Moreover, it shows both agonist and antagonist activities at receptors HTR2B and ADRA1A, albeit at low affinity. The compound also has notable effects on liver toxicity, including moderate and acute hepatotoxicity and granulomatous hepatitis, though it is not significantly associated with chronic liver disease or tumors. With a LogP of 2.38, Tiliquinol has moderate hydrophobicity, which, along with its pKa values, suggest it possesses properties that may influence its solubility, permeability, and interaction with biological targets. Specifically, it inhibits liver catechol-O-methyltransferase activity in Sprague-Dawley rats with an IC50 of 44668.36 nM. Overall, while Tiliquinol displays a variety of bioactivities and potential therapeutic effects, its relatively low potency in many of the tested assays warrants further investigation to optimize its pharmacological properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Tiliquinol (NSC-130828) (NSC-130828) is a non-absorbed luminal agent with anti-amoebic properties that is often used in conjunction with tibroquinol. It is commonly employed in the study and investigation of amebic liver abscesses.
别名	甲羟喹, NSC 130828

化学信息

分子量	159.18
分子式	C₁₀H₉NO
CAS No.	5541-67-3
Smiles	Cc1ccc(O)c2ncccc12

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 90 mg/mL (565.4 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (20.73 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2822 mL	31.4110 mL	62.8220 mL	314.1098 mL
5 mM	1.2564 mL	6.2822 mL	12.5644 mL	62.8220 mL
10 mM	0.6282 mL	3.1411 mL	6.2822 mL	31.4110 mL
20 mM	0.3141 mL	1.5705 mL	3.1411 mL	15.7055 mL
50 mM	0.1256 mL	0.6282 mL	1.2564 mL	6.2822 mL
100 mM	0.0628 mL	0.3141 mL	0.6282 mL	3.1411 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。