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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Stictic Acid

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纯度: 97.07%

货号 T35673Cas号 549-06-4

别名 斑点酸, Scopularic acid

Stictic Acid (Scopularic acid) 分离自苏门答腊地衣 Stereocaulon montagneanum，可抑制 HT-29 人结肠腺癌细胞的生长，IC50 为 29.29 μg/ml。

Stictic Acid
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Stictic Acid

一键复制产品信息
Rating icon 很棒

纯度: 97.07%

货号 T35673 别名 斑点酸, Scopularic acidCas号 549-06-4

Stictic Acid (Scopularic acid) 分离自苏门答腊地衣 Stereocaulon montagneanum，可抑制 HT-29 人结肠腺癌细胞的生长，IC50 为 29.29 μg/ml。

规格价格库存数量
500 μg
¥ 1,490
5日内发货
1 mg
¥ 2,220
5日内发货
5 mg
¥ 5,130
5日内发货
10 mg
¥ 6,970
5日内发货
1 mL x 10 mM (in DMSO)
¥ 5,120
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产品介绍

Stictic Acid AI Summary
Stictic Acid exhibits a wide range of bioactivities across various biological systems. It shows potent bioactivity against HIV-1 integrase, inhibiting both 3'-processing and strand transfer activities with strong IC50 values. The compound also demonstrates inhibitory effects against disintegration of HIV-1 integrase, albeit with a higher IC50 value. Additionally, it inhibits the uptake of sodium fluorescein in OATP1B1- and OATP1B3-transfected CHO cells, exhibits low cytotoxicity against human HL60, HeLa, and African green monkey Vero cells, and shows good chemical stability in methanol. In growth retardation studies, Stictic Acid affects the larval and pupal weight and duration of Spodoptera littoralis larvae. It also inhibits various enzymes and proteins, including Phosphoglycerate Kinase, Glutaminase, translin/trax in E. coli, and soluble guanylate cyclase (sGC) in human and bovine cells. The compound shows antibacterial activity against several strains like Klebsiella pneumoniae MDR, Staphylococcus aureus MRSA, Pseudomonas aeruginosa, and Escherichia coli, but weaker antifungal activity. Notably, it demonstrates a degree of inhibition against SARS-CoV-2 3CL-Pro protease and SARS-CoV-2 induced cytotoxicity in VERO-6 cells. Further bioactivities include the inhibition of enzymes such as PHPT1, FabZ from Yersinia pestis and Francisella tularensis, and Salmonella typhimurium LsrK kinase. Stictic Acid also affects interactions in signaling pathways by inhibiting p115 DHPH22 domain interaction with RhoA F25N mutant, indicating its potential in modulating these pathways. In sum, Stictic Acid is a multi-target bioactive molecule with significant inhibition capabilities across diverse biological processes and pathogens..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Stictic Acid (Scopularic acid) is isolated from a Sumatran lichen Stereocaulon montagneanum and inhibits the growth of HT-29 human colon adenocarcinoma cells with an IC50 of 29.29 μg/ml.
别名斑点酸, Scopularic acid
化学信息
分子量386.31
分子式C19H14O9
CAS No.549-06-4
SmilesOC1C=2C3=C(C(C)=C(O)C2C(=O)O1)OC(=O)C=4C(O3)=C(C=O)C(OC)=CC4C
密度1.591 g/cm3 (Predicted)
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 11 mg/mL (28.47 mM), Sonication is recommended.
DMF: Soluble
Methanol: Soluble
Ethanol: Soluble
溶液配制表
DMSO
1mg5mg10mg50mg
1 mM2.5886 mL12.9430 mL25.8859 mL129.4297 mL
5 mM0.5177 mL2.5886 mL5.1772 mL25.8859 mL
10 mM0.2589 mL1.2943 mL2.5886 mL12.9430 mL
20 mM0.1294 mL0.6471 mL1.2943 mL6.4715 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

Stictic Acid
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