Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Piperilate, also known as Pipethanate, is a hetrazepine derivative PAF antagonist and anticholinergic mixture, commonly utilized in bronchial asthma research. This compound exhibits hypotensive properties and has been found to effectively counteract the toxic effects of organophosphates in mice [1] [2] [3].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Piperilate, also known as Pipethanate, is a hetrazepine derivative PAF antagonist and anticholinergic mixture, commonly utilized in bronchial asthma research. This compound exhibits hypotensive properties and has been found to effectively counteract the toxic effects of organophosphates in mice [1] [2] [3]. |
体内活性 | Piperilate (11.3 mg/kg, 29.42 mg/kg; i.p.; single dose) shows anticholinergic activity, and (30 mg/kg; i.p.; single dose) exerts efficacy in mice poisoned by the organophosphates [1]. Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine [2]. Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline -induced constriction of an isolated rabbit auricle preparation [2]. Animal Model: Male albino mice (18-22 g) [1] Dosage: 11.3 mg/kg, 29.42 mg/kg Administration: Intraperitoneal injection; single dose Result: Showed anticholinergic activity with EC 50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice. |
分子量 | 339.43 |
分子式 | C21H25NO3 |
CAS No. | 4546-39-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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