PARP1/c-Met-IN-3 (Compound L19) is a selective inhibitor of c-Met and PARP1, with an IC50 of 5.4 nM for c-Met and 3.7 nM for PARP1. It also inhibits PARP2 enzyme activity, exhibiting an IC50 of 4.52 nM, and shows a lack of specificity between PARP1 and PARP2. PARP1/c-Met-IN-3 induces cell cycle arrest and apoptosis (Apoptosis) and demonstrates antitumor activity against triple-negative breast cancer.

c-Met:5.4 nM