Name: Pabinafusp alfa
Brand: TargetMol
SKU: T81573
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

待询

5 mg

待询

生物活性

产品描述	Pabinafusp alfa (JR-141), a transferrin receptor-targeting antibody fusing Iduronate 2-sulfatase with an anti-human transferrin receptor antibody, penetrates the blood-brain barrier and inhibits heparan sulfate (HS) accumulation within the central nervous system of mucopolysaccharidosis II (MPS II) mice. It enhances cognitive function and protects against neuronal damage in the central nervous system [1].
体内活性	Pabinafusp alfa（0.1-2 mg/kg；静脉注射；每周一次，持续36周）在剂量依赖性方面能够预防MPS II小鼠模型中神经组织的病理变化，并对神经缺陷有所改善[1]。
别名	JR-141
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

偶联与修饰

偶联	Unconjugated

抗原信息

靶点	transferrin

化学信息

CAS No.

2140211-48-7

储存&溶解度

存储	-20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Pabinafusp alfa