keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug.
产品描述 | OSK-1 is a potent potassium channel blocker belonging to the α-KTx3 toxins. It exhibits IC50 values of 0.6 nM, 5.4 nM, and 0.014 nM for Kv1.1, Kv1.2, and Kv1.3 channels, respectively. Additionally, OSK-1 acts as a moderate blocker of the calcium-activated KCa3.1 channel, with an IC50 of 225 nM. Consequently, OSK-1 finds application as an immunosuppressive drug. |
靶点活性 | Kv1.2:5.4 nM (IC50), KCa3.1:225 nM (IC50), Kv1.1:0.6 nM (IC50), Kv1.3:0.014 nM (IC50) |
体外活性 | OSK1 has no effect on K Ca 2.1, K Ca 2.2, K Ca 2.3 and K Ca 1.1 channels when in the micromolar concentration range, whereas it shows a moderate activity on K Ca 3.1 channel (also referred to as IK1 or SK4) with an IC 50 value of 225 nM[1]. |
体内活性 | OSK1 is lethal in mice by intracerebroventricular injection, with a LD 50 (50% lethal dose) value of 2 μg/kg[1]. |
分子量 | N/A |
CAS No. | 183815-75-0 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
OSK-1 183815-75-0 OSK 1 OSK1 Inhibitor inhibitor inhibit