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ACVR2B Protein, Mouse, Recombinant (His)

ACVR2B Protein, Mouse, Recombinant (His)

产品编号 TMPY-01281
别名: ActRIIB, activin A receptor, type IIB, 4930516B21Rik

ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1.

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ACVR2B Protein, Mouse, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 现货
200 μg ¥ 6,530 5日内发货
500 μg ¥ 13,220 5日内发货
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产品目录号及名称: ACVR2B Protein, Mouse, Recombinant (His) (TMPY-01281)
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生物活性
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参考文献
生物活性 1. Measured by its binding ability in a functional ELISA. Immobilized Mouse ACVR2B at 2μg/mL (100 μl/well) can bind biotinylated mouse INHBA-His , The EC50 of biotinylated mouse INHBA-His is 40-95 ng/mL. 2. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.2-0.8 µg/mL in the presence of 10 ng/mL recombinant Activin A.

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产品描述 ACVR2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P27040-1.
种属 Mouse
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P27040-1
别名 ActRIIB, activin A receptor, type IIB, 4930516B21Rik
蛋白构建 The extracellular domain of Mouse ACTRIIB (NP_031423.1) (Met 1-Thr 134) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度 > 94 % as determined by SDS-PAGE

TargetMol

分子量 14.8 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

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Keywords

ACVR2B Protein, Mouse, Recombinant (His) ActRIIB activin A receptor, type IIB 4930516B21Rik recombinant recombinant-proteins proteins protein

 

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