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ACVR2A Protein, Human, Recombinant (His)

ACVR2A Protein, Human, Recombinant (His)

产品编号 TMPY-01744
别名: activin A receptor, type IIA, ACVR2, ACTRII

ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1.

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ACVR2A Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
100 μg ¥ 3,170 现货
200 μg ¥ 5,600 5日内发货
500 μg ¥ 11,870 5日内发货
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产品目录号及名称: ACVR2A Protein, Human, Recombinant (His) (TMPY-01744)
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生物活性
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参考文献
生物活性 Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.4-3 µg/mL in the presence of 10 ng/mL recombinant Activin A.

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产品描述 ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1.
种属 Human
表达系统 HEK293 Cells
标签 C-His
蛋白编号 P27037-1
别名 activin A receptor, type IIA, ACVR2, ACTRII
蛋白构建 The extracellular domain of Human ACVR2A (NP_001607.1) (Met 1-Pro 134) was expressed, with a polyhistidine tag at the C-terminus.
蛋白纯度 ≥ 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

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分子量 14.9 kDa (predicted)
内毒素 < 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液 Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice.

研究背景 ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

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Keywords

ACVR2A Protein, Human, Recombinant (His) ACVR 2 activin A receptor, type IIA ACVR-2 ACVR2 ACTRII recombinant recombinant-proteins proteins protein

 

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