Name: ACVR2A Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01744
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 365

3日内发货

10 μg

¥ 585

3日内发货

20 μg

¥ 958

3日内发货

50 μg

¥ 1,880

3日内发货

100 μg

¥ 3,170

现货

200 μg

¥ 5,600

5日内发货

500 μg

¥ 11,870

5日内发货

生物活性

产品描述	ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1.
生物活性	Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.4-3 µg/mL in the presence of 10 ng/mL recombinant Activin A.
研究背景	ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.
种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P27037-1
蛋白构建	A DNA sequence encoding the extracellular domain of human ACVR2A (NP_001607.1) (Met 1-Pro 134) was expressed, with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 20
蛋白纯度	≥ 97 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
别名	ACVR2, ACTRII, activin A receptor, type IIA
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.