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顶部相关产品产品介绍化学信息储存和溶解信息计算器

N-(α-Linolenoyl) Tyrosine

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货号 T38222Cas号 259143-19-6

Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.

N-(α-Linolenoyl) Tyrosine

N-(α-Linolenoyl) Tyrosine

一键复制产品信息
Rating icon 还可以
货号 T38222Cas号 259143-19-6

Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.

规格价格库存数量
5 mg
¥ 1,790
35日内发货
10 mg
¥ 3,360
35日内发货
50 mg
¥ 13,900
35日内发货
100 mg
¥ 24,500
35日内发货
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产品介绍

生物活性
产品描述
Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.
化学信息
分子量441.6
分子式C27H39NO4
CAS No.259143-19-6
SmilesC([C@H](NC(CCCCCCC/C=C\C/C=C\C/C=C\CC)=O)C(O)=O)C1=CC=C(O)C=C1
密度no data available
Sequence{α-Linolenoyl}-Tyr
Sequence Short{α-Linolenoyl}-Y
储存&溶解度
存储
溶解度信息
DMF: 30 mg/mL (67.93 mM), Sonication is recommended.
PBS (pH 7.2): 1 mg/mL (2.26 mM), Sonication is recommended.
Ethanol: 30 mg/mL (67.93 mM), Sonication is recommended.
DMSO: 30 mg/mL (67.93 mM), Sonication is recommended.
溶液配制表
PBS (pH 7.2)/DMF/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.2645 mL11.3225 mL22.6449 mL113.2246 mL
DMF/Ethanol/DMSO
1mg5mg10mg50mg
5 mM0.4529 mL2.2645 mL4.5290 mL22.6449 mL
10 mM0.2264 mL1.1322 mL2.2645 mL11.3225 mL
20 mM0.1132 mL0.5661 mL1.1322 mL5.6612 mL
50 mM0.0453 mL0.2264 mL0.4529 mL2.2645 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL， 一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH2O， 那么您的工作液浓度为2 mg/mL。
母液配置方法：2 mg 药物溶于 100 μL DMSO （ 母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法： 取 100 μL DMSO 母液， 添加 400 μL PEG300 混匀澄清， 再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH2O 混匀澄清
以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。
方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD， 玉米油等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

剂量转换

对于不同动物的给药剂量换算，您也可以参考 更多

关键词

N-(α-Linolenoyl) TyrosineN(αLinolenoyl) TyrosineN-(alpha-Linolenoyl) TyrosineN-(a-Linolenoyl) TyrosineN (α Linolenoyl) Tyrosine
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