Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mitobronitol (Myelobromol; DBM) 是甘露醇的溴化类似物。Mitobronitol 是被归类为烷化剂的抗癌剂。Mitobronitol 具有骨髓抑制作用,可显著降低加速慢性粒细胞白血病异体骨髓移植的几种并发症的风险。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | Mitobronitol (Myelobromol; DBM) is a brominated analog of mannitol. Mitobronitol is an anticancer agent classified as an alkylating agent. Mitobronitol shows myelosuppression effect that significantly reduced risk for several complications of allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia [1] [2]. |
体内活性 | Mitobronitol (850 mg/kg; i.p.; single dose) improves spleen cells to mitogens and enhances thymus regeneration in mice model [2]. Animal Model: Female BALB/c mice (8-10 weeks old) [2] Dosage: 850 mg/kg; 1500 mg/kg (suspended in 5% Tween 80 in saline, 0.5 mL) Administration: Intraperitoneal injection; single dose Result: Showed effect on the in vitro proliferative response of spleen cells to mitogens at 850 mg/kg. Enhanced thymus regeneration and was earlier than control, with the starting resititution time-course of 2 weeks and subtotal resititution time course of 3 weeks under 1500 mg/kg dose. |
分子量 | 307.97 |
分子式 | C6H12Br2O4 |
CAS No. | 488-41-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Mitobronitol 488-41-5 Inhibitor inhibitor inhibit