Name: Laccase-IN-3
Brand: TargetMol
SKU: T209746
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

50 mg

待询

产品介绍

生物活性

产品描述	Laccase-IN-3 (Compound 2b) is a laccase inhibitor with an IC50 of 1.02 μM, demonstrating significant antifungal activity. It effectively inhibits Botryosphaeria dothidea with an EC50 of 0.17 mg/L. By binding to the active site of laccase, Laccase-IN-3 disrupts its catalytic function and also compromises the integrity of the pathogen's cell membrane while increasing reactive oxygen species (ROS).
体外活性	Laccase-IN-3 (25 mg/L) 对真菌的抑制活性分别为 98.2% (B. dothidea)、92% (S. sclerotiorum)、93.9% (F. graminearum)、53.1% (B. cinerea)、59.9% (P. capsici)、22.0% (P. infestans)、81.5% (P. nicotianae)。对真菌的 EC50 为 0.17 mg/L (B. dothidea)、2.55 mg/L (S. sclerotiorum)、2.03 mg/L (F. graminearum)。Laccase-IN-3 (0.79-6.25 mg/L) 通过改变 B. dothidea 菌丝的结构抑制其生长。此外，Laccase-IN-3 (10-25 mg/L; 120 min) 破坏 B. dothidea 菌丝体的细胞膜完整性，增加膜透性，降低细胞外 pH，扰乱细胞内环境稳定。
体内活性	Laccase-IN-3 (100, 200 mg/L; 6 天) 对感染 B. dothidea 的 apple 显示出显著的保护活性（92.6% 和 86.8%）以及治疗活性（85.0% 和 78.9%），均优于 Boscalid。