Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HBV-IN-25 is a novel chemical compound that acts as a potent HBV cccDNA reducer when administered orally. It exhibits significant anti-HBeAg potency and anti-HBV activity, with IC50 values of 0.58 μM and 1.15 μM, respectively. Moreover, HBV-IN-25 demonstrates favorable aqueous solubility (LYSA>452 μg/mL) and no cellular toxicity, making it a promising candidate for further investigation and development [1].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | HBV-IN-25 is a novel chemical compound that acts as a potent HBV cccDNA reducer when administered orally. It exhibits significant anti-HBeAg potency and anti-HBV activity, with IC50 values of 0.58 μM and 1.15 μM, respectively. Moreover, HBV-IN-25 demonstrates favorable aqueous solubility (LYSA>452 μg/mL) and no cellular toxicity, making it a promising candidate for further investigation and development [1]. |
体外活性 | HBV-IN-25 (8-50 μM, 5 days) has anti-HBeAg potency with an IC 50 value of 0.58 μM. HBV-IN-25 (8-50 μM, 5 days) has the anti-HBV activity in PHH is maintained or slightly decreased with IC 50 value of 1.15 μM [1]. |
体内活性 | HBV-IN-25 (oral, 5, 20, 100, 300 mg/kg, single) has good PK property, and also shows excellent efficacy in significantly reducing HBV antigens, DNA, and intrahepatic cccDNA levels [1]. Pharmacokinetic Parameters of HBV-IN-25 inHBVcircle mouse model (oral, 5, 20, 100, 300 mg/kg, single) [1]. Dose Terminal body weight % versus day 1 Spinal cord inflammation Foci per 20 cells Spinal cord demyelination Score 0–5 Spinal cord apoptotic cells Count per section PK parameter 5 mg/kg PO 20 mg/kg PO 100 mg/kg PO 300 mg/kg PO C max (ng/kg) 828 8157 32200 59900 T max (ng/kg) 0.25 0.5 0.5 2.67 AUC 0 ∞ (ng h/mL) 857 11,818 119,960 453,367 t 1/2 (h) 3.46 3.45 1.82 dose-normalized C max [(ng/mL)/(mg/kg)] 166 408 322 200 Dose-normalized AUC 0 24h [(ng h/mL)/(mg/kg)] 171 591 1200 1511 Animal Model: HBVcircle mouse model [1] Dosage: 5, 20, 100, 300 mg/kg Administration: oral, 5, 20, 100, 300 mg/kg, single Result: |
分子量 | 343.76 |
分子式 | C18H14ClNO4 |
CAS No. | 2161364-69-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
HBV-IN-25 2161364-69-6 Inhibitor inhibitor inhibit