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Dioxybenzone

Name: Dioxybenzone
Brand: TargetMol
SKU: T0698
Price: 145 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.39%

货号 T0698Cas号 131-53-3

别名 二羟苯宗, UV-24, Dioxybenzon, Cyasorb UV 24, Benzophenone-8, Advastab 47, 2,2'-Dihydroxy-4-methoxybenzophenone

Dioxybenzone (Benzophenone-8) 是一种能够阻断 UVB 和短波 UVA 紫外线照射的有机试剂。

Dioxybenzone

一键复制产品信息

很棒

纯度: 99.39%

货号 T0698 别名 二羟苯宗, UV-24, Dioxybenzon, Cyasorb UV 24, Benzophenone-8, Advastab 47, 2,2'-Dihydroxy-4-methoxybenzophenoneCas号 131-53-3

Dioxybenzone (Benzophenone-8) 是一种能够阻断 UVB 和短波 UVA 紫外线照射的有机试剂。

规格	价格	库存
50 mg	¥ 145	现货
100 mg	¥ 192	现货
500 mg	¥ 415	现货
1 g	¥ 597	现货
1 mL x 10 mM (in DMSO)	¥ 466	现货

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实验操作小课堂

常见问题解答

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纯度: 99.39%

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

Dioxybenzone AI Summary

Dioxybenzone exhibits a broad spectrum of bioactivities across various assays. It demonstrates potency as a modulator of Lamin A splicing, inhibitors and substrates of Cytochrome P450 enzymes (2C19 and 3A4), and both agonists and antagonists of the Hypoxia Response Element Signaling Pathway. It acts as an inhibitor of enzymes such as HPGD and 15-human lipoxygenase and activates Cytochrome P450 3A4. It also shows activity against the malarial parasite plastid, delayed death inhibitors, DNA re-replication in colon adenocarcinoma cells, human tyrosyl-DNA phosphodiesterase 1 (TDP-43), and various viral entry blockers. Additionally, Dioxybenzone is effective in inhibiting sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 87.65% and 85.43% at 10 µM, respectively. The compound exhibits antiviral activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 cells with an inhibition rate of 11.04% at a 10 µM concentration after 48 hours. It also demonstrates 7.352% inhibition of the SARS-CoV-2 3CL-Pro protease at a 20 µM concentration. However, its inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 shows a lower activity with an inhibition index of 0.507 relative to the arbidol control. Dioxybenzone shows inhibition of the human HDAC6 enzyme activity with 8.93% and 6.28% inhibition in enzymatic assays using commercial and custom peptide substrates, respectively. It further exhibits binding affinity towards receptors like SLC6A2 and ADORA3, antagonistic activity at human TBXA2R and CHRM1, and agonistic activity at human HTR2B and ADRA1A receptors. In summary, Dioxybenzone displays inhibitory, binding, antagonistic, and agonistic properties across various biological targets and assays, indicating its potential for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Dioxybenzone (Benzophenone-8) is an organic agent that blocks UVB and short-wave UVA ultraviolet radiation.
别名	二羟苯宗, UV-24, Dioxybenzon, Cyasorb UV 24, Benzophenone-8, Advastab 47, 2,2'-Dihydroxy-4-methoxybenzophenone

化学信息

分子量	244.24
分子式	C₁₄H₁₂O₄
CAS No.	131-53-3
Smiles	C(=O)(C1=C(O)C=C(OC)C=C1)C2=C(O)C=CC=C2
密度	1.296 g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

Ethanol: 45 mg/mL (184.25 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 65 mg/mL (266.13 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.19 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0943 mL	20.4717 mL	40.9433 mL	204.7167 mL
5 mM	0.8189 mL	4.0943 mL	8.1887 mL	40.9433 mL
10 mM	0.4094 mL	2.0472 mL	4.0943 mL	20.4717 mL
20 mM	0.2047 mL	1.0236 mL	2.0472 mL	10.2358 mL
50 mM	0.0819 mL	0.4094 mL	0.8189 mL	4.0943 mL
100 mM	0.0409 mL	0.2047 mL	0.4094 mL	2.0472 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

UV24 UV 24 Dioxybenzone Benzophenone8 Benzophenone 8

Dioxybenzone

Dioxybenzone

Dioxybenzone 相关产品

产品介绍

计算器

体内实验配液计算器

剂量转换

引用文献

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